Platelet-rich plasma: Growth factor enhancement for bone grafts
Received 1 October 1997; received in revised form 17 December 1997; accepted 8 January 1998.
Abstract
Platelet-rich plasma is an autologous source of platelet-derived growth factor and transforming growth factor beta that is obtained by sequestering and concentrating platelets by gradient density centrifugation. This technique produced a concentration of human platelets of 338% and identified platelet-derived growth factor and transforming growth factor beta within them. Monoclonal antibody assessment of cancellous cellular marrow grafts demonstrated cells that were capable of responding to the growth factors by bearing cell membrane receptors. The additional amounts of these growth factors obtained by adding platelet-rich plasma to grafts evidenced a radiographic maturation rate 1.62 to 2.16 times that of grafts without platelet-rich plasma. As assessed by histomorphometry, there was also a greater bone density in grafts in which platelet-rich plasma was added (74.0% ± 11%) than in grafts in which platelet-rich plasma was not added (55.1% ± 8%; p = 0.005).
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University of Miami School of Medicine, Miami, Fla., USA
Reprint requests: Robert E. Marx, DDS Division of Oral and Maxillofacial Surgery University of Miami School of Medicine 5000 University Drive Coral Gables, FL 33146
a Professor of Surgery and Chief, Division of Oral and Maxillofacial Surgery.
b Associate Professor of Surgery, Division of Oral and Maxillofacial Surgery.
c Staff Oral and Maxillofacial Surgeon, Veterans Affairs Medical Center, Dayton, Ohio; formerly, Fellow, Tumor and Reconstructive Surgery, University of Miami School of Medicine.
d Assistant Professor of Surgery, Department of Oral Surgery, Oral Medicine, Oral Pathology, Indiana University School of Dentistry; formerly, Fellow, Tumor and Reconstructive Surgery, University of Miami School of Medicine.
ABSTRACT