Proinflammatory cytokines in temporomandibular joint synovial fluid before and after arthrocentesis
Received 25 September 2008; received in revised form 12 January 2009; accepted 5 February 2009.
Objective
The aim of this study was to evaluate the levels of interleukin (IL)-1β, IL-6, IL-8, IL-11, and tumor necrosis factor (TNF)-α in temporomandibular joint (TMJ) synovial fluid of the patients with internal derangement before and 2 weeks after arthrocentesis.
Study design
Forty TMJs of 35 patients (29 females and 6 males, mean age 22.9 years) were included to the study. TMJs were divided into 2 groups: disc displacement with reduction (Group 1, n = 24) and disc displacement without reduction (Group 2, n = 16). Synovial fluid samples were obtained before and 2 weeks after arthrocentesis. IL-1β, IL-6, IL-8, IL-11, and TNF-α concentrations were measured by using specific kits.
Results
Two weeks after the arthrocentesis procedures, all cytokines were found to be significantly decreased (P < .05) both in Group 1 and Group 2. The difference between 2 groups was insignificant (P > .05).
Conclusion
Arthrocentesis is an effective technique for eliminating the studied cytokines from the TMJ synovial fluid.
aResident, Selcuk University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Konya, Turkey
bAssociate Professor, Selcuk University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Konya, Turkey
cAssociate Professor, Selcuk University, Faculty of Veterinary Medicine, Department of Biochemistry, Konya, Turkey
dResident, Baskent University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ankara, Turkey
Reprint requests: Kubilay Isik, DDS, PhD, Baskent Universitesi, Konya Uygulama ve Arastirma Merkezi, Konya, Turkiye
ABSTRACT