Effect of ERK inhibitor on pulmonary metastasis of inoculated human adenoid cystic carcinoma cells in nude mice
Received 9 January 2009; received in revised form 13 July 2009; accepted 24 July 2009.
In this study, we detected the expression of phosphylated ERK1/2 in human salivary adenoid cystic carcinoma (SACC) by immunohistochemical method, the effect of various concentrations of PD98059 on the growth of ACC-M cells (a cell line of human adenoid cystic carcinoma of the salivary glands) by MTT assay, and the effect of PD98059 on the lung metastasis of inoculated ACC-M cells in nude mice. The results showed that the phosphylated ERK1/2 was overexpressed in SACC, the ACC-M cell line proliferation was inhibited by PD98059, and the lung metastasis level was reduced by PD98059, indicating that ERK may be a key molecule in targeted therapy of adenoid cystic carcinoma.
aChief physician, College of Stomatology, Zhejiang University, Hangzhou, China
bAttending doctor, College of Stomatology, Zhejiang University, Hangzhou, China
cResident physician, College of Stomatology, Zhejiang University, Hangzhou, China
Reprint requests: Miss Yining Li, Oral Pathology, College of Stomatology, Zhejiang University, Yan-an Road 395, Hangzhou, Zhejiang 310031, China
ABSTRACT