Effect of recombinant basic fibroblast growth factor on reimplanted teeth in beagle dogs
Received 27 February 2009; received in revised form 31 July 2009; accepted 31 July 2009. published online 02 November 2009.
Objectives
This study assessed the effect of recombinant fibroblast growth factor (FGF-2) on reimplanted teeth.
Study design
Premolars were reimplanted in dogs. Roots on the left side of the mandible were treated with FGF-2, whereas roots on right side served as controls. At 2, 4, or 8 weeks after treatment, animals were humanely killed and specimens collected and processed for histopathologic examination.
Results
After 2 weeks, proliferating cell nuclear antigen-positive cell ratios in the experimental group were significantly greater than those in the control group (P < .01). After 4 and 8 weeks, the experimental group showed formation of new cementum. Moreover, incidence of replacement resorption in the experimental group was significantly lower than that in the control group (P < .01).
Conclusion
The results indicate that FGF-2 promotes formation of new periodontal ligament and prevents ankylosis and root resorption following reimplantation of teeth.
aResident, Department of Periodontics, Tokyo Dental College, Chiba, Japan
bSenior Assistant Professor, Department of Periodontics, Tokyo Dental College, Chiba, Japan
cAssistant Professor, Department of Periodontics, Tokyo Dental College, Chiba, Japan
dAssociate Professor, Department of Periodontics, Tokyo Dental College, Chiba, Japan
eProfessor, Department of Periodontics, Tokyo Dental College, Chiba, Japan
Reprint requests: Fumi Seshima, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba-shi, Chiba pref., Tokyo, Japan
ABSTRACT